Nikolaos A. Patsopoulos, M.D. and Ph.D., along with colleagues, had been investigating MS susceptibility. To find the consequences of novel susceptibility loci, a one-stage meta-analysis was done. There were seven genome-wide associated studies that involved 2,529,395 unique nucleotide polymorphisms. These morphisms were obtained from 5,545 patients who had MS and 12,153 control patients. 228 individuals were used for quantitative trait analysis in peripheral blood mononuclear cells. These individuals had demyelinating disease. From this experiment, the researchers were able to identify three new susceptibility alleles.
This discovery is said to add to the list of loci that are linked with MS. Before now, this list was made up of only past genome scans. The new alleles also help researchers to confirm their theory that increasing sample size will lead to new discoveries in MS susceptibility loci.