Drug Pipeline

Stage Drug Name AKA LAB
Pre-clinical Glial Growth Factor 2 GGF2 Acorda
Pre-clinical AEG35156 XIAP antagonist Aegera
Pre-clinical NAPVSIPQ NAP Allon
Pre-clinical AT-008 Androclus
Pre-clinical CD83 Argos Therapeutics
Pre-clinical AZD 8797 AstraZeneca
Pre-clinical ESPRIT Exon Skipping Pre-RNA Interference AVI BioPharma
Pre-clinical CF101 Can Fite BioPharma
Pre-clinical CF402 Can Fite BioPharma
Pre-clinical Neurodur CepTor
Pre-clinical Nicotinamide a form of vitamin B3 Children’s Hospital – Boston
Pre-clinical LLDT-8 Chinese Academy of Sciences
Pre-clinical Interferon-beta – electroporation EP-mediated intramuscul ar IFN-beta gene transfer Cleveland Clinic
Pre-clinical CGEN-54 Compugen
Pre-clinical Peptidomimetics of apoE protein apolipoprotein, COG133 Duke University
Pre-clinical Neutrazumab C5a Receptor antagonist G2 Therapies
Pre-clinical GEMS-001 Gemacbio
Pre-clinical CD3 antibodies Harvard
Pre-clinical HE3204 Hollis-Eden
Pre-clinical Vitamin B12 Hospital for Sick Children – Toronto
Pre-clinical Epratuzumab IMMU-103 Immunomedics
Pre-clinical Bowmann-Birk Inhibitor Concentrate BBIC Jefferson Medical College
Pre-clinical CEP-701 Johns Hopkins
Pre-clinical 13-cis-retinoic acid Kinemed
Pre-clinical Fasudil Kyushu University
Pre-clinical LJP 1207 La Jolla Pharmaceuticals
Pre-clinical hBCMA-Fc La Trobe University – Australia
Pre-clinical LX2931 Lexicon Genetics
Pre-clinical Calpeptin calpain-specific inhibitor Medical U of S Carol ina
Pre-clinical sTNFR:Fc/p80 Medical University of Lodz, Poland
Pre-clinical 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside AIC AR Medical University of South Carolina
Pre-clinical Cathepsin S Medivir
Pre-clinical MT203 human anti-GM-CSF IgG1 antibody Micromet AG
Pre-clinical Mikbeta1 National Institutes of Health
Pre-clinical OPN-101 Opsona
Pre-clinical BVA-101 Biovista
Pre-clinical DP IV and APN inhibition Otto-von-Guericke University, Ger many
Pre-clinical ROB 895 Oxypharma
Pre-clinical Tetracycline non-antibacterial Paratek
Pre-clinical PXS2076 Pharmaxis
Pre-clinical PXS25 / PXS64 Pharmaxis
Pre-clinical Q-Cells Q Therapeutics
Pre-clinical QR-442 Quigley
Pre-clinical Aequorin Quincy Bioscience
Pre-clinical Timcodar Recovexx
Pre-clinical RheoSwitch Therapeutic System + TriGrid Delivery System Rh eoGene, Ichor Medical Systems
Pre-clinical R348 Rigel
Pre-clinical Gemfibrozil Lopid Rush University
Pre-clinical IL-1ra gene therapy San Raffaele Scientific Institute, Mil an
Pre-clinical CRA-028129 cathepsin S inhibitor Schering
Pre-clinical DZ2002 Shanghai Institute of Materia Medica
Pre-clinical CYLA calpain inhibitor SUNY Downstate Medical Center
Pre-clinical STA-5326 Synta Pharmaceuticals
Pre-clinical Syntonix Transceptor/SynFusion inhaled interferon-beta:Fc Syntonix/Serono
Pre-clinical ONO-2506 arundic acid Takizawa et al
Pre-clinical Oral Copaxone Teva
Pre-clinical Glucosamine Thomas Jefferson University
Pre-clinical ShK L5 UC Irvine
Pre-clinical Estrogen receptor alpha ERalpha ligand UCLA
Pre-clinical LF 15-0195 Universite Paul Sabatier, France
Pre-clinical 15d-PGJ University of Arkansas
Pre-clinical PLP-BPI University of Kansas
Pre-clinical MTA methylthioadenosine University of Navarra – Spain
Pre-clinical CT301 University of Western Ontario
Pre-clinical VX15 Vaccinex and Teva
Pre-clinical Symadex imidazoacridinone Xanthus
Pre-clinical Dilantin phenytoin Yale University
Pre-clinical Vasoactive Intestinal Peptide VIP
Pre-clinical CHR-1103 Chromos
Pre-clinical Ciliary neurotrophic factor CNTF
Pre-clinical MCT-175 MultiCell
Pre-clinical Arvanil synthetic capsaicin-anandamide hybrid
Phase III Revimmune high-dose cyclophosphamide or cytoxan Accentia Biopharmaceuticals
Phase III BG12 Biogen
Phase III Interferon beta 1a – PEGylated bi-weekly or monthly injection Biogen Idec
Phase III MBP8298 Dirucotide BioMS
Phase III Cannabinoids – oral PPMS Clinical Neurology Research Group – Plymouth
Phase III Campath alemtuzumab Genzyme
Phase III Progestin and Estradiol Hospices Civils de Lyon
Phase III MN-166 ibudilast and Ketas Medicinova
Phase III Mylinax oral cladribine Merck Serono
Phase III Minocycline MS Society of Canada, MS Scientific Research Foundation
Phase III FTY720 fingolimod Novartis
Phase III Trimesta oral Pipex Pharmaceuticals
Phase III Teriflunomide HMR 1726 Sanofi-Aventis
Phase III T-Cell Vaccination TCV-01-002 Sheba Medical Center
Phase III Laquinimod ABR-215062 Teva
Phase III Mycophenolate mofetil Cellcept with Avonex
Phase III Stem cells – autologous hematopoietic ASTIMS trial
Phase II AB1010 Kinavet or Masitinib AB Science
Phase II ATL/TV 1102 Antisense Therapeutics / Teva
Phase II ATX-MS1467 Apitope Technology / Merck Serono
Phase II Flupirtine Bayer / Schering
Phase II BHT-3009-01 DNA vaccine Bayhill Therapeutics
Phase II ESP an analogue of a metabolite of azathioprine Biomolecular Pharma / Mount Allison University
Phase II Chaperonin 10 XToll and Cpn10 C-Bio
Phase II Pixantrone BBR 2778 Cell Therapeutics
Phase II EGCg Epigallocatechin-Gallate Charite University, Berlin
Phase II Enkorten FAR404 Farmacija
Phase II GEM-SP SPMS Gemacbio
Phase II Ofatumumab HuMax-CD20 Genmab
Phase II Lamotrigine Lamictal Glaxosmithkline
Phase II Firategrast SB-683699 and T-0047 Glaxosmithkline / Tanabe
Phase II Autologous hematopoietic stem cell transplantation HALT MS and Northwestern University
Phase II Alferon N Injection Hemispherx Biopharma
Phase II LymphoStat-B belimumab Human Genome Sciences, Glaxosmithkline
Phase II RG2077 CTLA4-IgG4m Immune Tolerance Network and Repligen
Phase II Zocor simvastatin Merck Serono
Phase II Atacicept TACI-Ig Merck Serono and ZymoGenetics
Phase II Pravastatin Nantes University Hospital – France
Phase II Omega-3 fatty acid Norway
Phase II Kynurenine Tranilast, Rizoben, 3,4-DAA Nuon Therapeutics
Phase II RPI-78M Nutra Pharma / ReceptoPharm
Phase II Tovaxin Opexa
Phase II Lipitor atorvastatin Pfizer
Phase II Daclizumab Zenapax Protein Design Labs, Biogen-Idec
Phase II Ocrelizumab R1594 Roche/Genentech/Biogen
Phase II MBP8298 BioMS RRMS trial
Phase II Estroprogestins with IFN beta 1a S. Andrea Hospital
Phase II HP184 nerispirdine Sanofi-Aventis
Phase II Vitamin D3 with calcium St. Michael’s Hospital – Toronto
Phase II Erythropoietin EPO Stem Cell Therapeutics
Phase II Lymphocytapheresis, azathioprine & prednisone SPMS U of Chicago
Discontinued CDP323 UCB / Biogen
Phase II Testosterone UCLA
Phase II Riluzole with Avonex UCSF
Phase II Hookworm WIRMS – Worms for Immune Regulation in MS UK
Phase II Fluoxetine Prozac University Medical Center Groningen
Phase II Mesenchymal Stem Cells University of Cambridge and Hadassah Medical Organization
Phase II Stem cell transplant from donor not autologous University of Louisville
Phase II Interferon alpha oral University of Texas-Houston
Phase II Treosulfan SPMS University of Wuerzburg, Germany
Phase II Minocycline
Phase II Low-dose naltrexone LDN
Phase II Bacille Calmette-Guèrin BCG Vaccine
Phase II Doxycycline with Avonex
Phase II Methotrexate – intrathecal
Phase I RTL1000 Artielle ImmunoTherapeutics
Phase I AZD5904 AstraZeneca
Phase I BaroFeron BaroFold
Phase I BCX-4208 DADMe-Immunicillin-H or R3421 BioCryst and Roche
Phase I BGC20-0134 BTG
Phase I CCX915 CCR2 antagonist ChemoCentryx
Phase I Mesenchymal stem cell transplantation autologous Cleveland Clinic
Phase I CS-0777 Daiichi-Sankyo
Phase I TBC-4746 Encysive Pharmaceuticals / Pfizer
Phase I Valomaciclovir EPB-348 Epiphany Biosciences
Phase I Far Infrared Irradiation GAAD Medical Research Institute, Canada
Phase I GRC 4039 Glenmark Pharmaceuticals
Phase I INCB8696 Incyte
Phase I TK54 LTKfarma
Phase I MM-093 Recombinant Human Alpha-Fetoprotein Merrimack
Phase I MLN0415 Millenium / Sanofi-Aventis
Phase I NI-0401 NovImmune
Phase I ONO-4641 oral S1P receptor agonist Ono Pharmaceutical
Phase I Lipoic acid Oregon Health and Science University
Phase I Low Fat Diet Oregon Health and Science University
Phase I Amiloride Oxford University
Phase I Cannabinor Pharmos
Phase I R1295 Roche
Phase I R3477 Roche / Actelion
Phase I Helminth-induced immunomodulation therapy HINT U of Wisconsin
Phase I Extracorporeal photochemotherapy University of Milano-Bicocca
Phase I Linoleic Acid omega-6 University of Rochester
Phase I SC12267 4SC AG
Phase I Sildenafil Citrate Viagra
Phase I PI-2301 Peptimmune
Off-label Mycophenolate mofetil Cellcept
Off-label Cyclophosphamide Cytoxan
Off-label Azathioprine Imuran
Off-label Plasma exchange plasmapheresis
Off-label Intravenous Immune Globulin IVIg
Off-label Low-Dose Naltrexone LDN
Off-label Antibiotics: Doxycycline, Amoxicillin, Rifampin, Metronidazole — OR — Doxycycline, Roxithromycin, Metronidazole — OR — Rifampin, Azithromycin, Flagyl
Off-label Methotrexate
Approved Betaseron / Extavia subcutaneous interferon beta 1b Bayer / Novartis
Approved Avonex intramuscular interferon beta 1a Biogen Idec
Approved Tysabri natalizumab Biogen Idec / Elan
Approved Rebif new formulation: fetal bovine serum-free/human serum albumin-free Merck Serono
Approved Novantrone mitoxantrone Merck Serono / OSI
Approved Copaxone glatiramir acetate Teva

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